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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | W | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Red Ruffing# | 266 | 1924-1946 | |
| 2 | Ted Lyons# | 262 | 1923-1946 | |
| 3 | Mel Harder# | 212 | 1928-1945 | |
| 4 | Tommy Bridges# | 194 | 1930-1946 | |
| 5 | Bucky Walters# | 184 | 1931-1946 | |
| 6 | Bobo Newsom# | 183 | 1929-1946 | |
| 7 | Bill Lee# | 162 | 1934-1946 | |
| 8 | Curt Davis# | 158 | 1934-1946 | |
| 8 | Claude Passeau# | 158 | 1935-1946 | |
| 10 | Hal Schumacher# | 156 | 1931-1946 | |
| 11 | Dutch Leonard# | 132 | 1933-1946 | |
| 12 | Schoolboy Rowe# | 125 | 1933-1946 | |
| 13 | Bob Feller# | 119 | 1936-1946 | |
| 14 | Mort Cooper# | 115 | 1938-1946 | |
| 15 | Thornton Lee# | 113 | 1933-1946 | |
| 16 | Harry Gumbert# | 112 | 1935-1944 | |
| 17 | Rip Sewell# | 110 | 1932-1946 | |
| 18 | Dizzy Trout# | 102 | 1939-1946 | |
| 19 | Bill Dietrich# | 101 | 1933-1946 | |
| 20 | Hal Newhouser# | 93 | 1939-1946 | |
| 21 | Si Johnson# | 89 | 1928-1943 | |
| 21 | Johnny Murphy# | 89 | 1932-1943 | |
| 23 | Fritz Ostermueller# | 87 | 1934-1946 | |
| 24 | Jim Bagby# | 85 | 1938-1945 | |
| 24 | Spud Chandler# | 85 | 1937-1946 | |
| 26 | Denny Galehouse# | 84 | 1934-1946 | |
| 27 | Jack Knott# | 82 | 1933-1942 | |
| 28 | Kirby Higbe# | 79 | 1937-1946 | |
| 29 | Johnny Vander Meer# | 78 | 1937-1946 | |
| 30 | Tiny Bonham# | 76 | 1940-1946 | |
| 30 | George Caster# | 76 | 1934-1946 | |
| 32 | Max Lanier# | 75 | 1938-1946 | |
| 33 | Mace Brown# | 73 | 1935-1943 | |
| 34 | Hank Borowy# | 72 | 1942-1946 | |
| 34 | Nels Potter# | 72 | 1936-1946 | |
| 36 | Al Hollingsworth# | 67 | 1935-1946 | |
| 37 | Al Benton# | 66 | 1934-1946 | |
| 37 | Eddie Smith# | 66 | 1936-1946 | |
| 39 | Tex Hughson# | 64 | 1941-1946 | |
| 40 | Johnny Niggeling# | 63 | 1938-1946 | |
| 41 | Bob Klinger# | 62 | 1938-1943 | |
| 41 | Clyde Shoun# | 62 | 1935-1946 | |
| 43 | Bob Muncrief# | 61 | 1937-1946 | |
| 44 | Johnny Rigney# | 57 | 1937-1946 | |
| 45 | Al Milnar# | 56 | 1936-1943 | |
| 45 | Steve Sundra# | 56 | 1936-1944 | |
| 47 | Johnny Lanning# | 54 | 1936-1945 | |
| 47 | Mike Ryba# | 54 | 1935-1946 | |
| 49 | Al Javery# | 53 | 1940-1945 | |
| 49 | Hank Wyse# | 53 | 1942-1946 | |
| 51 | Johnny Humphries# | 52 | 1938-1946 | |
| 52 | Roger Wolff# | 51 | 1941-1946 | |
| 53 | Red Barrett# | 49 | 1937-1946 | |
| 54 | Orval Grove# | 47 | 1940-1946 | |
| 54 | Ed Heusser# | 47 | 1935-1946 | |
| 56 | Hugh Casey# | 46 | 1935-1946 | |
| 57 | Harry Brecheen# | 45 | 1940-1946 | |
| 57 | Jack Kramer# | 45 | 1939-1946 | |
| 57 | Marius Russo# | 45 | 1939-1943 | |
| 60 | Mickey Haefner# | 43 | 1943-1946 | |
| 60 | Hugh Mulcahy# | 43 | 1935-1945 | |
| 62 | Early Wynn# | 42 | 1939-1946 | |
| 63 | Ace Adams# | 41 | 1941-1945 | |
| 63 | Allie Reynolds# | 41 | 1942-1946 | |
| 65 | Joe Haynes# | 40 | 1939-1946 | |
| 65 | Sid Hudson# | 40 | 1940-1942 | |
| 67 | Joe Dobson# | 39 | 1939-1946 | |
| 67 | Bill Posedel# | 39 | 1938-1941 | |
| 67 | Junior Thompson# | 39 | 1939-1942 | |
| 67 | Bill Voiselle# | 39 | 1942-1946 | |
| 71 | Nate Andrews# | 38 | 1937-1945 | |
| 72 | Russ Christopher# | 37 | 1942-1946 | |
| 72 | Harry Feldman# | 37 | 1941-1946 | |
| 72 | Howie Krist# | 37 | 1937-1943 | |
| 72 | Virgil Trucks# | 37 | 1941-1946 | |
| 72 | Bill Zuber# | 37 | 1936-1945 | |
| 77 | Steve Gromek# | 36 | 1941-1946 | |
| 77 | Nick Strincevich# | 36 | 1940-1946 | |
| 79 | Jesse Flores# | 35 | 1942-1946 | |
| 79 | Preacher Roe# | 35 | 1938-1946 | |
| 81 | Joe Beggs# | 33 | 1938-1944 | |
| 82 | Lum Harris# | 32 | 1941-1944 | |
| 83 | Hal Gregg# | 31 | 1943-1946 | |
| 83 | Vern Olsen# | 31 | 1939-1946 | |
| 83 | Stubby Overmire# | 31 | 1943-1946 | |
| 83 | Charlie Wagner# | 31 | 1938-1942 | |
| 87 | Russ Bauers# | 30 | 1936-1946 | |
| 87 | Ed Lopat# | 30 | 1944-1946 | |
| 87 | Phil Marchildon# | 30 | 1940-1946 | |
| 87 | Ernie White# | 30 | 1940-1946 | |
| 91 | Johnny Gorsica# | 29 | 1940-1944 | |
| 91 | Ken Heintzelman# | 29 | 1937-1942 | |
| 91 | Oscar Judd# | 29 | 1941-1946 | |
| 94 | Hi Bithorn# | 28 | 1942-1946 | |
| 95 | Joe Krakauskas# | 27 | 1937-1946 | |
| 95 | Jake Wade# | 27 | 1936-1946 | |
| 97 | Art Herring# | 26 | 1929-1945 | |
| 98 | Al Gerheauser# | 25 | 1943-1946 | |
| 98 | Ed Head# | 25 | 1940-1946 | |
| 100 | Bob Carpenter# | 24 | 1940-1942 |
