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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | W | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Red Ruffing# | 265 | 1924-1945 | |
| 2 | Ted Lyons# | 260 | 1923-1946 | |
| 3 | Mel Harder# | 212 | 1928-1945 | |
| 4 | Tommy Bridges# | 193 | 1930-1946 | |
| 5 | Bobo Newsom# | 180 | 1929-1946 | |
| 5 | Bucky Walters# | 180 | 1931-1946 | |
| 7 | Bill Lee# | 159 | 1934-1945 | |
| 8 | Curt Davis# | 158 | 1934-1945 | |
| 9 | Hal Schumacher# | 154 | 1931-1942 | |
| 10 | Claude Passeau# | 151 | 1935-1946 | |
| 11 | Dutch Leonard# | 126 | 1933-1946 | |
| 12 | Schoolboy Rowe# | 121 | 1933-1946 | |
| 13 | Mort Cooper# | 113 | 1938-1946 | |
| 13 | Bob Feller# | 113 | 1936-1946 | |
| 15 | Harry Gumbert# | 112 | 1935-1944 | |
| 16 | Thornton Lee# | 111 | 1933-1946 | |
| 17 | Rip Sewell# | 110 | 1932-1946 | |
| 18 | Bill Dietrich# | 99 | 1933-1945 | |
| 19 | Dizzy Trout# | 98 | 1939-1946 | |
| 20 | Si Johnson# | 89 | 1928-1943 | |
| 20 | Johnny Murphy# | 89 | 1932-1943 | |
| 20 | Hal Newhouser# | 89 | 1939-1946 | |
| 23 | Jim Bagby# | 85 | 1938-1945 | |
| 24 | Jack Knott# | 82 | 1933-1942 | |
| 24 | Fritz Ostermueller# | 82 | 1934-1946 | |
| 26 | Denny Galehouse# | 81 | 1934-1946 | |
| 27 | Spud Chandler# | 80 | 1937-1946 | |
| 28 | Kirby Higbe# | 78 | 1937-1943 | |
| 29 | Tiny Bonham# | 75 | 1940-1946 | |
| 29 | Johnny Vander Meer# | 75 | 1937-1946 | |
| 31 | George Caster# | 74 | 1934-1945 | |
| 32 | Mace Brown# | 73 | 1935-1943 | |
| 33 | Max Lanier# | 69 | 1938-1946 | |
| 34 | Hank Borowy# | 68 | 1942-1946 | |
| 35 | Al Hollingsworth# | 67 | 1935-1945 | |
| 35 | Nels Potter# | 67 | 1936-1946 | |
| 37 | Al Benton# | 63 | 1934-1946 | |
| 37 | Eddie Smith# | 63 | 1936-1943 | |
| 39 | Bob Klinger# | 62 | 1938-1943 | |
| 40 | Clyde Shoun# | 61 | 1935-1944 | |
| 41 | Bob Muncrief# | 59 | 1937-1946 | |
| 41 | Johnny Niggeling# | 59 | 1938-1946 | |
| 43 | Tex Hughson# | 58 | 1941-1946 | |
| 44 | Al Milnar# | 56 | 1936-1943 | |
| 44 | Johnny Rigney# | 56 | 1937-1946 | |
| 44 | Steve Sundra# | 56 | 1936-1944 | |
| 47 | Johnny Lanning# | 54 | 1936-1945 | |
| 48 | Al Javery# | 53 | 1940-1945 | |
| 49 | Johnny Humphries# | 52 | 1938-1945 | |
| 49 | Mike Ryba# | 52 | 1935-1946 | |
| 51 | Hank Wyse# | 49 | 1942-1946 | |
| 52 | Red Barrett# | 47 | 1937-1946 | |
| 52 | Orval Grove# | 47 | 1940-1946 | |
| 52 | Ed Heusser# | 47 | 1935-1946 | |
| 52 | Roger Wolff# | 47 | 1941-1946 | |
| 56 | Hugh Casey# | 46 | 1935-1942 | |
| 57 | Marius Russo# | 45 | 1939-1943 | |
| 58 | Jack Kramer# | 43 | 1939-1946 | |
| 58 | Hugh Mulcahy# | 43 | 1935-1945 | |
| 60 | Ace Adams# | 41 | 1941-1945 | |
| 61 | Harry Brecheen# | 40 | 1940-1946 | |
| 61 | Sid Hudson# | 40 | 1940-1942 | |
| 61 | Allie Reynolds# | 40 | 1942-1945 | |
| 61 | Early Wynn# | 40 | 1939-1946 | |
| 65 | Mickey Haefner# | 39 | 1943-1946 | |
| 65 | Bill Posedel# | 39 | 1938-1941 | |
| 65 | Junior Thompson# | 39 | 1939-1942 | |
| 68 | Nate Andrews# | 38 | 1937-1945 | |
| 69 | Howie Krist# | 37 | 1937-1943 | |
| 69 | Bill Zuber# | 37 | 1936-1945 | |
| 71 | Russ Christopher# | 36 | 1942-1946 | |
| 71 | Joe Haynes# | 36 | 1939-1945 | |
| 71 | Bill Voiselle# | 36 | 1942-1946 | |
| 74 | Joe Dobson# | 35 | 1939-1946 | |
| 74 | Harry Feldman# | 35 | 1941-1945 | |
| 74 | Nick Strincevich# | 35 | 1940-1945 | |
| 77 | Joe Beggs# | 33 | 1938-1944 | |
| 78 | Steve Gromek# | 32 | 1941-1946 | |
| 78 | Lum Harris# | 32 | 1941-1944 | |
| 80 | Charlie Wagner# | 31 | 1938-1942 | |
| 81 | Vern Olsen# | 30 | 1939-1946 | |
| 81 | Virgil Trucks# | 30 | 1941-1946 | |
| 81 | Ernie White# | 30 | 1940-1946 | |
| 84 | Russ Bauers# | 29 | 1936-1946 | |
| 84 | Johnny Gorsica# | 29 | 1940-1944 | |
| 84 | Ken Heintzelman# | 29 | 1937-1942 | |
| 87 | Jesse Flores# | 28 | 1942-1946 | |
| 87 | Preacher Roe# | 28 | 1938-1946 | |
| 89 | Hi Bithorn# | 27 | 1942-1946 | |
| 89 | Hal Gregg# | 27 | 1943-1946 | |
| 89 | Phil Marchildon# | 27 | 1940-1945 | |
| 89 | Stubby Overmire# | 27 | 1943-1946 | |
| 93 | Art Herring# | 26 | 1929-1945 | |
| 94 | Oscar Judd# | 25 | 1941-1945 | |
| 94 | Jake Wade# | 25 | 1936-1946 | |
| 96 | Bob Carpenter# | 24 | 1940-1942 | |
| 96 | Ed Head# | 24 | 1940-1946 | |
| 96 | Joe Krakauskas# | 24 | 1937-1946 | |
| 96 | Rube Melton# | 24 | 1941-1944 | |
| 100 | Al Gerheauser# | 23 | 1943-1945 |
