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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | K | YEAR | Open Postseason Leaderboard |
|---|---|---|---|---|
| 1 | Red Ruffing# | 61 | 1924-1945 | |
| 2 | Mort Cooper# | 35 | 1938-1946 | |
| 3 | Tommy Bridges# | 27 | 1930-1946 | |
| 3 | Schoolboy Rowe# | 27 | 1933-1946 | |
| 5 | Max Lanier# | 25 | 1938-1946 | |
| 6 | Hal Newhouser# | 22 | 1939-1946 | |
| 7 | Bobo Newsom# | 17 | 1929-1946 | |
| 7 | Hal Schumacher# | 17 | 1931-1942 | |
| 9 | Spud Chandler# | 15 | 1937-1946 | |
| 9 | Denny Galehouse# | 15 | 1934-1946 | |
| 11 | Tiny Bonham# | 14 | 1940-1946 | |
| 12 | Hank Borowy# | 13 | 1942-1946 | |
| 12 | Bill Lee# | 13 | 1934-1945 | |
| 14 | Jack Kramer# | 12 | 1939-1946 | |
| 14 | Bucky Walters# | 12 | 1931-1946 | |
| 16 | Dizzy Trout# | 10 | 1939-1946 | |
| 17 | Blix Donnelly# | 9 | 1944-1945 | |
| 18 | Johnny Murphy# | 8 | 1932-1943 | |
| 19 | Harry Brecheen# | 7 | 1940-1946 | |
| 19 | Marius Russo# | 7 | 1939-1943 | |
| 19 | Virgil Trucks# | 7 | 1941-1946 | |
| 19 | Ted Wilks# | 7 | 1944-1945 | |
| 23 | Johnny Beazley# | 6 | 1941-1942 | |
| 23 | Nels Potter# | 6 | 1936-1946 | |
| 23 | Ernie White# | 6 | 1940-1946 | |
| 26 | Al Benton# | 5 | 1934-1946 | |
| 26 | Paul Erickson# | 5 | 1941-1946 | |
| 26 | Junior Thompson# | 5 | 1939-1942 | |
| 29 | Al Brazle# | 4 | 1943-1946 | |
| 29 | Johnny Gorsica# | 4 | 1940-1944 | |
| 29 | Bob Muncrief# | 4 | 1937-1946 | |
| 32 | Harry Gumbert# | 3 | 1935-1944 | |
| 32 | Claude Passeau# | 3 | 1935-1946 | |
| 34 | Stubby Overmire# | 2 | 1943-1946 | |
| 34 | Steve Sundra# | 2 | 1936-1944 | |
| 34 | Johnny Vander Meer# | 2 | 1937-1946 | |
| 37 | Joe Beggs# | 1 | 1938-1944 | |
| 37 | Hugh Casey# | 1 | 1935-1942 | |
| 37 | George Caster# | 1 | 1934-1945 | |
| 37 | Curt Davis# | 1 | 1934-1945 | |
| 37 | Kirby Higbe# | 1 | 1937-1943 | |
| 37 | Al Hollingsworth# | 1 | 1935-1945 | |
| 37 | Fred Hutchinson# | 1 | 1939-1946 | |
| 37 | Ray Prim# | 1 | 1933-1946 | |
| 37 | Freddy Schmidt# | 1 | 1944-1944 | |
| 37 | Tex Shirley# | 1 | 1941-1945 | |
| 37 | Hank Wyse# | 1 | 1942-1946 | |
| 48 | Bob Chipman# | 0 | 1941-1946 | |
| 48 | Murry Dickson# | 0 | 1939-1946 | |
| 48 | Johnny Hutchings# | 0 | 1940-1945 | |
| 48 | Al Jurisich# | 0 | 1944-1945 | |
| 48 | Howie Krist# | 0 | 1937-1943 | |
| 48 | Howie Pollet# | 0 | 1941-1946 |
